Professor of Oncology

Mikhail Blagosklonny



Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
G Kroemer, L Galluzzi, P Vandenabeele, J Abrams, ES Alnemri, ...
Cell death & differentiation 16 (1), 3-11
30392009Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
L Galluzzi, I Vitale, JM Abrams, ES Alnemri, EH Baehrecke, ...
Cell Death & Differentiation 19 (1), 107-120
23162012Stabilization of wild-type p53 by hypoxia-inducible factor 1α
WG An, M Kanekal, MC Simon, E Maltepe, MV Blagosklonny, LM Neckers
Nature 392 (6674), 405-408
9951998Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
L Galluzzi, I Vitale, SA Aaronson, JM Abrams, D Adam, P Agostinis, ...
Cell Death & Differentiation 25 (3), 486-541
9472018Classification of cell death: recommendations of the Nomenclature Committee on Cell Death
G Kroemer, WS El-Deiry, P Golstein, ME Peter, D Vaux, P Vandenabeele, ...
Cell death and differentiation 12 (12), 1463-1467
8122005Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
L Galluzzi, JM Bravo-San Pedro, I Vitale, SA Aaronson, JM Abrams, ...
Cell Death & Differentiation 22 (1), 58-73
7112015Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
L Galluzzi, SA Aaronson, J Abrams, ES Alnemri, DW Andrews, ...
Cell Death & Differentiation 16 (8), 1093-1107
6392009Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms
V Sandor, S Bakke, RW Robey, MH Kang, MV Blagosklonny, J Bender, ...
Clinical Cancer Research 8 (3), 718-728
6362002Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association
TW Schulte, MV Blagosklonny, C Ingui, L Neckers
Journal of Biological Chemistry 270 (41), 24585-24588
5071995Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway
MV Blagosklonny, T Schulte, P Nguyen, J Trepel, LM Neckers
Cancer Research 56 (8), 1851-1854
4931996The restriction point of the cell cycle
MV Blagosklonny, AB Pardee
Cell cycle 1 (2), 102-109
4902002Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death
MV Blagosklonny, P Giannakakou, WS El-Deiry, DGI Kingston, PI Higgs, ...
Cancer research 57 (1), 130-135
4641997Molecular effects of paclitaxel: myths and reality (a critical review)
MV Blagosklonny, T Fojo
International journal of cancer 83 (2), 151-156
4291999p53 is associated with cellular microtubules and is transported to the nucleus by dynein
P Giannakakou, DL Sackett, Y Ward, KR Webster, MV Blagosklonny, ...
Nature cell biology 2 (10), 709-717
4042000Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90
MV Blagosklonny, J Toretsky, S Bohen, L Neckers
Proceedings of the National Academy of Sciences 93 (16), 8379-8383
3781996Rapamycin decelerates cellular senescence
ZN Demidenko, SG Zubova, EI Bukreeva, VA Pospelov, TV Pospelova, ...
Cell cycle 8 (12), 1888-1895
3652009p53 inhibits hypoxia-inducible factor-stimulated transcription
MV Blagosklonny, WG An, LY Romanova, J Trepel, T Fojo, L Neckers
Journal of Biological Chemistry 273 (20), 11995-11998
3621998Aging: Ros or tor
MV Blagosklonny
Cell cycle 7 (21), 3344-3354
3532008P21-dependent G 1 arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228
V Sandor, A Senderowicz, S Mertins, D Sackett, E Sausville, ...
British journal of cancer 83 (6), 817-825
3462000Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway.
TW Schulte, MV Blagosklonny, L Romanova, JF Mushinski, BP Monia, ...
Molecular and cellular biology 16 (10), 5839-5845
3101996Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs
MV Blagosklonny
Leukemia 16 (4), 455-462
3072002Growth stimulation leads to cellular senescence when the cell cycle is blocked
ZN Demidenko, MV Blagosklonny
Cell cycle 7 (21), 3355-3361
2962008Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition
MV Blagosklonny
Cell cycle 5 (18), 2087-2102
2912006Antiangiogenic therapy and tumor progression
MV Blagosklonny
Cancer cell 5 (1), 13-17
2822004Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
VN Anisimov, MA Zabezhinski, IG Popovich, TS Piskunova, ...
Cell cycle 10 (24), 4230-4236
2802011In vitro evaluation of a p53‐expressing adenovirus as an anti‐cancer drug
MV Blagosklonny, WS El‐Deiry
International journal of cancer 67 (3), 386-392
2661996Protease inhibitor-induced apoptosis: accumulation of wt p53, p21 WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition
WG An, SG Hwang, JB Trepel, MV Blagosklonny
Leukemia 14 (7), 1276-1283
2652000Proteasome-dependent regulation of p21WAF1/CIP1Expression
MV Blagosklonny, GS Wu, S Omura, WS El-Deiry
Biochemical and biophysical research communications 227 (2), 564-569
2651996Taxol induction of p21WAF1 and p53 requires c-raf-1
MV Blagosklonny, TW Schulte, P Nguyen, EG Mimnaugh, J Trepel, ...
Cancer research 55 (20), 4623-4626
2651995The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
LG Korotchkina, OV Leontieva, EI Bukreeva, ZN Demidenko, AV Gudkov, ...
Aging (Albany NY) 2 (6), 344
2612010Paradoxical suppression of cellular senescence by p53
ZN Demidenko, LG Korotchkina, AV Gudkov, MV Blagosklonny
Proceedings of the National Academy of Sciences 107 (21), 9660-9664
2562010Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity
P Giannakakou, R Robey, T Fojo, MV Blagosklonny
Oncogene 20 (29), 3806-3813
2562001Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity
MV Blagosklonny, R Robey, DL Sackett, L Du, F Traganos, ...
Molecular cancer therapeutics 1 (11), 937-941
2472002Mitotic arrest and cell fate: why and how mitotic inhibition of transcription drives mutually exclusive events
MV Blagosklonny
Cell cycle 6 (1), 70-74
2382007Exploiting cancer cell cycling for selective protection of normal cells
MV Blagosklonny, AB Pardee
Cancer research 61 (11), 4301-4305
2322001Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism
K Salnikow, W Su, MV Blagosklonny, M Costa
Cancer research 60 (13), 3375-3378
2312000Growth and aging: a common molecular mechanism
MV Blagosklonny, MN Hall
Aging 1 (4), 357
2192009Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics
P Giannakakou, M Nakano, KC Nicolaou, A O'Brate, J Yu, ...
Proceedings of the National Academy of Sciences 99 (16), 10855-10860
2192002Rapamycin extends maximal lifespan in cancer-prone mice
VN Anisimov, MA Zabezhinski, IG Popovich, TS Piskunova, ...
The American journal of pathology 176 (5), 2092-2097
2172010The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia
K Salnikow, T Kluz, M Costa, D Piquemal, ZN Demidenko, K Xie, ...
Molecular and cellular biology 22 (6), 1734-1741
2142002Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging
MV Blagosklonny
Aging (Albany NY) 4 (3), 159
2092012Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans)
MV Blagosklonny
Cell Cycle 9 (4), 683-688
2092010p53 from complexity to simplicity: mutant p53 stabilization, gain-of-function, and dominant-negative effect
MV BLAGOSKLONNY
The FASEB Journal 14 (13), 1901-1907
2082000Geldanamycin selectively destabilizes and conformationally alters mutated p53.
MV Blagosklonny, J Toretsky, L Neckers
Oncogene 11 (5), 933-939
2041995Bcl-xL is phosphorylated in malignant cells following microtubule disruption
MS Poruchynsky, EE Wang, CM Rudin, MV Blagosklonny, T Fojo
Cancer research 58 (15), 3331-3338
1951998P53: an ubiquitous target of anticancer drugs
MV Blagosklonny
International journal of cancer 98 (2), 161-166
1902002Carcinogenic nickel induces genes involved with hypoxic stress
K Salnikow, MV Blagosklonny, H Ryan, R Johnson, M Costa
Cancer research 60 (1), 38-41
1902000Target for cancer therapy: proliferating cells or stem cells
MV Blagosklonny
Leukemia 20 (3), 385-391
1872006Cell death beyond apoptosis
MV Blagosklonny
Leukemia 14 (8), 1502-1508
1872000Pseudo-DNA damage response in senescent cells
TV Pospelova, ZN Demidenko, EI Bukreeva, VA Pospelov, AV Gudkov, ...
Cell cycle 8 (24), 4112-4118
1822009Cell cycle arrest is not senescence
MV Blagosklonny
Aging (Albany NY) 3 (2), 94
1792011Answering the ultimate question “what is the proximal cause of aging?”
MV Blagosklonny
Aging (Albany NY) 4 (12), 861
1712012Raf-1 and Bcl-2 induce distinct and common pathways that contribute to breast cancer drug resistance
JM Davis, PM Navolanic, CR Weinstein-Oppenheimer, LS Steelman, ...
Clinical Cancer Research 9 (3), 1161-1170
1692003Unwinding the loop of Bcl-2 phosphorylation
MV Blagosklonny
Leukemia 15 (6), 869-874
1662001Cell senescence and hypermitogenic arrest
MV Blagosklonny
EMBO reports 4 (4), 358-362
1652003Are p27 and p21 cytoplasmic oncoproteins?
MV Blagosklonny
Cell cycle 1 (6), 391-393
1622002The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy
MV Blagosklonny, T Fojo, KN Bhalla, JS Kim, JB Trepel, WD Figg, ...
Leukemia 15 (10), 1537-1543
1612001An anti-aging drug today: from senescence-promoting genes to anti-aging pill
MV Blagosklonny
Drug discovery today 12 (5-6), 218-224
1562007DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
OV Leontieva, MV Blagosklonny
Aging (Albany NY) 2 (12), 924
1542010Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program
MV Blagosklonny
Cell Cycle 9 (16), 3171-3176
1532010Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture
P Apontes, OV Leontieva, ZN Demidenko, F Li, MV Blagosklonny
Oncotarget 2 (3), 222
1512011Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors
K Salnikow, WG An, G Melillo, MV Blagosklonny, M Costa
Carcinogenesis 20 (9), 1819-1823
1511999Validation of anti-aging drugs by treating age-related diseases
MV Blagosklonny
Aging 1 (3), 281
1482009Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo
L Whitesell, P Sutphin, WG An, T Schulte, MV Blagosklonny, L Neckers
Oncogene 14 (23), 2809-2816
1481997Loss of function and p53 protein stabilization
MV Blagosklonny
Oncogene 15 (16), 1889-1893
1461997Hypoxia suppresses conversion from proliferative arrest to cellular senescence
OV Leontieva, V Natarajan, ZN Demidenko, LG Burdelya, AV Gudkov, ...
Proceedings of the National Academy of Sciences 109 (33), 13314-13318
1372012Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity
WG An, RC Schnur, L Neckers, MV Blagosklonny
Cancer chemotherapy and pharmacology 40 (1), 60-64
1361997Weak p53 permits senescence during cell cycle arrest
OV Leontieva, AV Gudkov, MV Blagosklonny
Cell cycle 9 (21), 4323-4327
1302010Flavopiridol, an inhibitor of transcription: implications, problems and solutions
MV Blagosklonny
Cell cycle 3 (12), 1537-1542
1292004Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs
MV Blagosklonny, R Robey, S Bates, T Fojo
The Journal of clinical investigation 105 (4), 533-539
1292000Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor
ZN Demidenko, MV Blagosklonny
Cancer research 64 (10), 3653-3660
1272004Prospective strategies to enforce selectively cell death in cancer cells
MV Blagosklonny
Oncogene 23 (16), 2967-2975
1212004Differential sensitivity of cancer cells to inhibitors of the epidermal growth factor receptor family
PC Bishop, T Myers, R Robey, DW Fry, ET Liu, MV Blagosklonny, ...
Oncogene 21 (1), 119-127
1192002Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice
EA Komarova, MP Antoch, LR Novototskaya, OB Chernova, ...
Aging (Albany NY) 4 (10), 709
1182012Conceptual biology: unearthing the gems
MV Blagosklonny, AB Pardee
Nature 416 (6879), 373-373
1182002Why therapeutic response may not prolong the life of a cancer patient: selection for oncogenic resistance
MV Blagosklonny
Cell cycle 4 (12), 1693-1698
1132005Effects of p53-expressing adenovirus on the chemosensitivity and differentiation of anaplastic thyroid cancer cells
MV Blagosklonny, P Giannakakou, M Wojtowicz, LY Romanova, KB Ain, ...
The Journal of Clinical Endocrinology & Metabolism 83 (7), 2516-2522
1121998Teratogens as anticancer drugs
MV Blagosklonny
Cell cycle 4 (11), 1518-1521
1102005At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence
ZN Demidenko, MV Blagosklonny
Cell Cycle 8 (12), 1901-1904
1092009Cancer stem cell and cancer stemloids: from biology to therapy
MV Blagosklonny
Cancer biology & therapy 6 (11), 1684-1690
1092007A Phase II study of high-dose tamoxifen in patients with hormone-refractory prostate cancer
RC Bergan, E Reed, CE Myers, D Headlee, O Brawley, HK Cho, WD Figg, ...
Clinical Cancer Research 5 (9), 2366-2373
1091999Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects …
MV Blagosklonny
Leukemia 15 (6), 936-941
1072001Hyperinducibility of hypoxia-responsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer
K Salnikow, M Costa, WD Figg, MV Blagosklonny
Cancer research 60 (20), 5630-5634
1062000Prevention of cancer by inhibiting aging
MV Blagosklonny
Cancer biology & therapy 7 (10), 1520-1524
1042008Cell senescence: hypertrophic arrest beyond the restriction point
MV Blagosklonny
Journal of cellular physiology 209 (3), 592-597
1032006Matching targets for selective cancer therapy
MV Blagosklonny
Drug discovery today 24 (8), 1104-1107
1022003Mitogen-activated protein kinase pathway is dispensable for microtubule-active drug-induced Raf-1/Bcl-2 phosphorylation and apoptosis in leukemia cells
MV Blagosklonny, Y Chuman, RC Bergan, T Fojo
Leukemia 13 (7), 1028-1036
1021999TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists
MV Blagosklonny
Cell death & disease 4 (12), e964-e964
1002013Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression
OV Leontieva, MV Blagosklonny
Aging (Albany NY) 3 (11), 1078
1002011Hypoxia-inducible factor: Achilles' heel of antiangiogenic cancer therapy
MV Blagosklonny
International journal of oncology 19 (2), 257-262
1002001Oncogenic resistance to growth-limiting conditions
MV Blagosklonny
Nature reviews Cancer 2 (3), 221-224
992002Mechanism of G1-like arrest by low concentrations of paclitaxel: next cell cycle p53-dependent arrest with sub G1 DNA content mediated by prolonged mitosis
ZN Demidenko, S Kalurupalle, C Hanko, CU Lim, E Broude, ...
Oncogene 27 (32), 4402-4410
972008Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program
OV Leontieva, ZN Demidenko, MV Blagosklonny
Proceedings of the National Academy of Sciences 111 (24), 8832-8837
962014Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug
I Mercier, J Camacho, K Titchen, DM Gonzales, K Quann, KG Bryant, ...
The American journal of pathology 181 (1), 278-293
962012Rapamycin and quasi-programmed aging: Four years later
M Blagosklonny
Cell Cycle 9 (10), 1859-1862
962010Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence
ZN Demidenko, M Shtutman, MV Blagosklonny
Cell cycle 8 (12), 1896-1900
962009Cyclotherapy: protection of normal cells and unshielding of cancer cells
MV Blagosklonny, Z Darzynkiewicz
Cell cycle 1 (6), 375-382
962002Aging is not programmed: genetic pseudo-program is a shadow of developmental growth
MV Blagosklonny
Cell cycle 12 (24), 3736-3742
952013Acute overexpression of wt p53 facilitates anticancer drug‐induced death of cancer and normal cells
MV Blagosklonny, WS El‐Deiry
International journal of cancer 75 (6), 933-940
931998Loss of Maged1 results in obesity, deficits of social interactions, impaired sexual behavior and severe alteration of mature oxytocin production in the hypothalamus
C Dombret, T Nguyen, O Schakman, JL Michaud, H Hardin-Pouzet, ...
Human molecular genetics 21 (21), 4703-4717
90*2012
When people discuss today’s medicine, accuracy plays one of the most significant roles and people’s lives are literally dependent on it. Hence, any researches related to medicine are required to comply with the top standards. The problem today is that any outcomes of researches can be posted online and used as a reference without being precisely checked and validated. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this challenge and attempted to come up with an alternative solution. That’s how a weekly oncology-focused research journal called “Oncotarget” has been established back in 2010. The key principle of this journal is based on Altmetric scores that are used as a quality indicator. That assists both readers and authors to validate publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication.” Oncotarget website provides a complete publications list with corresponding scores above 100 as well as reports discussed previously. Mikhail (Misha) Blagosklonny glad to share his new approach and hopes it creates the necessary assistance to anybody, who has interest in oncology.
Zoya Demidenko
“A diagnostic autoantibody signature for primary cutaneous melanoma” has the Altmetric score of 594. This article was released back in 2018 by Oncotarget and written by different experts from Hollywood Private Hospital, Edith Cowan University, Dermatology Specialist Group, St. John of God Hospital and The University of Western Australia. The introduction of the study discusses “recent data shows that Australians are four times more likely to develop a cancer of the skin than any other type of cancer”, and provides an insight on melanoma that “is curable by surgical excision in the majority of cases, if detected at an early stage.”
The publication has got an Altmetric score of 594. Mikhail (Misha) Blagosklonny realizes that majority of readers are willing to understand the very meaning of it. Based on the Altmetric website, the score indicates “how many people have been exposed to and engaged with a scholarly output.” Likewise, the paper about melanoma, was utilized for citations in different news articles 69 times. Besides that, it was mentioned in 2 online blogs, as well as 25 Tweets on Twitter and 1 Facebook post. FOX23 of Tulsa, Oklahoma has headlined their report on July 20, 2018 as “New blood test could detect skin cancer early”, using the main content of Australia study
Another Oncotarget’s study with a top score of 476, is “Biomarkers for early diagnosis of malignant mesothelioma: Do we need another moon-shot,”. This publication has appeared in 60 news stories, 1 online blog post and 6 Twitter posts. The majority of public may have come across a short overview only, however those who visit Mikhail (Misha) Blagosklonny at Oncotarget, do get useful scientific facts. Oncotarget is glad to have the ability to share with online customers this highly appreciated and top-quality information, that is trustworthy and reliable.
Misha Blagosklonny

Comments

  1. Het artikel is echt geweldig, bedankt! Kun je ook iets schrijven over software ontwikkelaar?

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